Yen CC, Yen CJ, Shan YS, et al. - Researchers conducted the study for examining the characteristics of combined hepatocellular–cholangiocarcinoma (cHCC-CCA) in comparison with those of other primary liver cancers by utilizing the updated World Health Organization (WHO) classification. From December 2007 to May 2018, 64 cHCC-CCA patients and 55 HCCscf patients were retrospectively analyzed. Survival in cHCC-CCA patients is intermediate between that of hepatocellular carcinoma and intrahepatic cholangiocarcinoma patients, and HBV infection and high levels of tumour-infiltrating lymphocytes predict favorable survival. The research presents clinical correlations for the new 2019 WHO classification.