Femia G, Faour A, Assad J, et al. - This study was undertaken to assess whether culprit lesion location has prognostic significance in dominant right coronary artery (RCA) ST‐elevation myocardial infarction (STEMI). Data were obtained and analyzed from consecutive patients with a dominant RCA STEMI who received either primary or rescue percutaneous coronary intervention between January 2003 and December 2016. Comparisons were performed between culprit lesions located proximal and distal to the origin of the last right ventricular (RV) marginal artery >1 mm in diameter, focusing on rates of sustained ventricular tachycardia, cardiogenic shock (CS), intra‐aortic balloon pump, temporary cardiac pacing and death. Findings revealed the presence of a higher rate of acute complications, such as CS and death, in relation to culprit lesions located proximal to the origin of the last RV marginal artery.