Patel SA, et al. - To further evaluate the premise that decreasing 5-year overall survival (OS) in patients with laryngeal cancer is related to increased nonsurgical management of stage III/IV disease, researchers used National Cancer Data Base to analyze larynx-preserving approaches with chemoradiation (CRT) or partial laryngectomy (PL) and total laryngectomy (TL) stratified by tumor and nodal burden to assess related trends in OS and patterns of use. Between 2003 and 2011, patients (n=8,703) who received CRT or upfront PL or TL with or without adjuvant therapy for stage III/IV (excluding T1 tumors) laryngeal squamous cell carcinoma were identified. For patients with non-T4, low nodal burden laryngeal cancer, surgical and nonsurgical approaches did not differ in terms of survival. Definitive CRT could be beneficial for patients with non-T4, high nodal burden disease. Total laryngectomy continued to be beneficial in patients with T4 disease.