Lipp I, et al. - In this investigation, researchers explored the connection between MRI-based metrics of white matter microstructure in multiple sclerosis (MS), ie, the extent to which metrics provide complementary vs redundant information. From 123 patients with MS, fractional anisotropy (FA), radial diffusivity (RD), myelin water fraction (MWF), and magnetization transfer ratio (MTR) were the four microstructural metrics gathered. Investigators found that MWF was most sensitive when discriminating T2-hyperintensity lesions (T2L) from normal appearing white matter (NAWM). On the other hand, MTR was most sensitive when discriminating T1L from NAWM and from T2L. When estimating microstructural damage in MS, the four investigated metrics of white matter damage (FA(z), RD(z), MTR(z) and MWF(z)) show good agreement. The study findings suggested that the metrics are at least somewhat connected with each other, but sensitive to the various pathological aspects. Using these differences could be beneficial in testing the effects of therapeutic interventions in clinical trials.