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Comparative quantitative lymph node assessment in localized esophageal cancer patients after R0 resection with and without neoadjuvant chemoradiation therapy

Journal of Gastrointestinal Surgery Aug 30, 2017

Giugliano DN, et al. – This study sought to quantify lymph node retrieval after R0 esophagectomy and to assess its impact on overall survival in induction therapy patients. Significantly lower total lymph node counts were observed in the induction therapy group, while positive lymph node counts and lymph node ratios did not differ from the upfront surgery group. Although the groups were similar regarding overall survival, it was decreased within the induction therapy cohort among those who had any positive lymph nodes retrieved at surgery. Findings confirmed that unstratified gross lymph node counts did not substantially relate to prognosis in the heterogeneous population of locally advanced esophageal cancer patients who could or could not have had neoadjuvant chemoradiation.
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