Pepe M, et al. - Among unselected patients, Polymer-Free Biolimus-Eluting Stent (PF-BES) was compared to Durable Polymer-Everolimus-Eluting stent (DP-EES). Overall 848 consecutive patients were included, comprising 306 patients treated with PF-BES and 542 with DP-EES. Researchers used a propensity score-matched population and a CHIP (Complex Higher-Risk and Indicated Patients) subpopulation to test the performance of the stents. They also carried out a per-lesion analysis on 1204 lesions (PF-BES= 424 vs DP-EES=780). In the matched population in a real-world setting, the observed performance of PF-BES was similar to that of DP-EES in terms of restenosis and stent thrombosis. Nonetheless, a higher restenosis occurrence was reported in the PF-BES group in the whole and CHIP populations, as well as in the per-lesion analysis.