Boltin D, Levi Z, Gingold-Belfer R, et al. - In order to find out if esomeprazole is more effective than other proton-pump inhibitors (PPI) in the context of quadruple therapy for H pylori eradication, researchers retrospectively distinguished 25- to 60-year-old individuals with a positive 13C-urea breath test and no prior laboratory or endoscopic test for H pylori infection. They retrieved pharmacy dispensation data. They analyzed a total of 7,896 individuals including 2,856 (36.2%) males, aged 40.4 ± 10.6 years. Of those, 78.1% received omeprazole, 20.1% received lansoprazole, 1.5% received esomeprazole, and 0.34% received pantoprazole together with antibiotics for H pylori eradication. An association was found between esomeprazole and a greater proportion of successful eradication. Those individuals who received quadruple therapy, a nonsignificant trend favored esomeprazole over omeprazole. Moreover, they noted that independent predictors of treatment success included older age and quadruple therapy. In comparison with other PPIs, it was noted that esomeprazole is more significant for H pylori eradication. For confirmation of findings among subjects receiving quadruple therapy, studies with larger subgroups are needed.