Oya J, Nakagami T, Hasegawa Y, et al. - Japanese patients with type 1 diabetes and type 2 diabetes exhibited not only similar decreases in glycated hemoglobin (HbA1c) but also similar gains in body mass index (BMI) with insulin degludec (IDeg) vs insulin glargine 300 U/mL (Gla300), 6 months after switching from other basal insulins.

• This study included 307 patients with type 1 diabetes and 294 patients with type 2 diabetes with HbA1c >7.0%.

• Comparisons of adjusted mean changes in HbA1c, BMI, and insulin doses between IDeg (IDeg group) and Gla300 (Gla300 group) switchers were performed.

• Both IDeg and Gla300 groups exhibited significantly reduced HbA1c, and there were similar adjusted mean changes in HbA1c (about −0.3% and −0.5% in type 1 diabetes and type 2 diabetes patients, respectively) as well as in BMI between both groups.

• IDeg selection was related to insulin dose reduction.

• In the IDeg group, mean alteration in insulin dose was slightly larger for dose reduction vs Gla300 group.