Alekseenko S, et al. - In the present study, the researchers sought to assess mucociliary clearance and mucosal morphology using high-speed videomicroscopy, and their correlation with markers of disease severity in children with acute (ARS) and chronic rhinosinusitis (CRS). In total, 67 children aged from 6 to 17 years involving 15 healthy children, 20 pediatric patients with ARS, and 32 cases with CRS were enlisted in the present study. The results of this study show significant alteration of mucociliary clearance and mucosal morphology and its connection with sinonasal inflammation and disease severity in patients with rhinosinusitis. Modulation of inflammation and ciliary function in both acute and chronic rhinosinusitis may be regarded as a possible method in the therapeutic and surgical management of the condition, given the strong correlation between altered mucociliary clearance and disease severity.