Chhoda A, Yousaf MN, Madhani K, et al. - In this study, researchers investigated a surveillance population of low-risk pancreatic cysts for the comorbidity burden and reported on their follow-up mortality outcomes. From a prospective pancreatic cyst database, they included individuals with low-risk cysts undergoing serial imaging during 2016. The baseline age-adjusted Charlson Comorbidity Index (age-CACI) was determined via reviewing electronic medical records. Performing prospective surveillance on 502 individuals, 440 individuals with low-risk suspected or presumed mucinous cysts were included. Cohort stratification was enabled by the median age-CACI of 4 into Low (age-CACI < 4) and High CACI (age-CACI ≥ 4) groups. The High CACI group had a significantly higher overall mortality (OM) compared with the Low CACI group. Findings overall suggest the value of incorporating this comorbidity assessment tool in making shared surveillance decisions among low-risk pancreatic cyst population.