Buse DC, et al. - Researchers sought to determine the correlation of headache pain intensity and monthly headache day (MHD) frequency with migraine comorbidities. They conducted MAST Study, a prospective, web-based survey, assessing US population samples of persons with migraine (using modified International Classification of Headache Disorders-3 beta criteria) and without migraine. Persons with migraine were eligible if they averaged ≥ 1 MHDs over the prior 3 months. Comorbidities “confirmed by a healthcare professional diagnosis” were supported by respondents from a record of 21 common cardiovascular, neurologic, psychiatric, sleep, respiratory, dermatologic, pain and medical comorbidities. Assessment of a total of 15,133 people with migraine (73.0% women, 77.7% White, mean age 43 years) and 77,453 controls (46.4% women, 76.8% White, mean age 52 years) was done in this analysis. Significantly higher likelihood of reporting insomnia, depression, anxiety, gastric ulcers/GI bleeding, angina and epilepsy, among other conditions, was observed in people with migraine. Comorbidities related to inflammation (psoriasis, allergy), psychiatric disorders (depression, anxiety) and sleep conditions (insomnia) were observed in correlation with increasing headache pain intensity. They observed correlation of increasing MHD frequency with increased risk for nearly all conditions and most prominent among those with comorbid gastric ulcers/GI bleeding, diabetes, anxiety, depression, insomnia, asthma, and allergies/hay fever.