Kyuregyan KK, Malinnikova EY, Soboleva NV, et al. - In various age cohorts of the Central European part of Russia’s general population, researchers investigated the prevalence of hepatitis C virus (HCV) and if HCV antigen testing is feasible for community screening programs. For anti-HCV, they tested sera from 2,027 volunteers. In an immunoblot, confirmation was obtained for all anti-HCV reactive samples, which were then analyzed for HCV antigen (HCV Ag), HCV RNA and HCV viral load. Findings revealed a low overall prevalence of HCV, except in individuals 60 years or older, who they recommended should be a target group for HCV screening. Also, a high agreement was identified between HCV RNA and HCV Ag, indicating the usefulness of HCV Ag testing to confirm active infection in screening programs.