Niemczyk NA, et al. - Given that high parity is associated with greater cardiovascular disease (CVD) among mid-life and older women, researchers assessed vascular adaptation across pregnancy in healthy first-time pregnant women. In this Maternal Vascular Adaptation to Healthy Pregnancy Study (Pittsburgh, PA, 2010–2015), 37 primigravid women were assessed in each trimester, 6–8 weeks after delivery, and 1–5 years postpartum with B-mode ultrasound imaging of common carotid artery (CCA) intima-media thickness (IMT) and inter-adventitial diameter (IAD) to assess associations with physical and cardiometabolic measures. Findings revealed that IAD increased and returned to 1st-trimester levels postpartum in uncomplicated first pregnancies vs CCA IMT which, even 2 years postpartum, was still enlarged. Compared to metabolic changes, maternal weight explained vascular changes better. Increased postpartum CCA IMT might persist and contribute to long-term CVD risk.