Sher DJ, et al. - In patients with oropharyngeal squamous cell carcinoma (OPSCC) treated with radiotherapy (RT) and primary surgery (PS), researchers assessed the differences in overall survival and key toxic effects. Findings suggested an equal viability of RT and PS as treatment options for OPSCC; therefore, there was a probability of the local therapy decisions to be individualized to each patient. Nonetheless, they noted an association of the frequent addition of chemotherapy with increased gastrostomy dependence in patients having RT, which may be relevant in clinical decision making. The multivariable analysis suggested an association of increasing age, female sex, and low income with inferior survival. Whereas, the treatment type was not seen to be associated with inferior survival.