Gerischer LM, et al. - Authors probed if multifrequency-magnetic resonance elastography (MMRE) can detect differences in hippocampal stiffness between patients with clinical diagnosis of dementia due to Alzheimer's Disease (AD) and healthy controls (HC) and also analyzed whether the combination of three MRI-derived parameters, ie, hippocampal stiffness, hippocampal volume and mean diffusivity (MD), improves diagnostic accuracy. In patients with clinical diagnosis of dementia of the AD type, they demonstrated reduced hippocampal stiffness and reduced hippocampal viscosity, as determined by MMRE. Findings revealed that by the combination with two other MRI-based hippocampal parameters diagnostic sensitivity was further improved.