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Combining advanced MRI and EEG techniques better explains long-term motor outcome after very preterm birth

Pediatric Research May 28, 2021

van’t Westende C, Steggerda SJ, Jansen L, et al. - This study was undertaken to investigate the association between motor outcome and advanced magnetic resonance imaging (MRI) and electroencephalography measures. Researchers conducted a prospective cohort study including a total of 64 very preterm born children, the motor outcome was evaluated at 9.83 (SD 0.70) years. Relationships between motor outcome and brain volumes (white matter, deep gray matter, cerebellum, and ventricles), white matter integrity (fractional anisotropy and mean, axial and radial diffusivity), and brain activity (upper alpha (A2) functional connectivity and relative A2 power) were explored. The independence of relationships with motor outcome was explored with a final model. The outcomes imply that a lasting interplay exists between brain structure and function that might underlie motor outcome at school age.

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