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Combined surgery and extensive intraoperative peritoneal lavage vs surgery alone for treatment of locally advanced gastric cancer: The SEIPLUS randomized clinical trial

JAMA Jul 23, 2019

Guo J, et al. - Through a multicenter randomized clinical trial with 550 adults, experts assessed short-term outcomes of subjects with advanced gastric cancer who received combined surgery and extensive intraoperative peritoneal lavage (EIPL) vs surgery alone from March 2016 to November 2017. In comparison with those who had only surgery, patients who had surgery plus EIPL showed lower mortality. Between subjects receiving only surgery vs those who received surgery plus EIPL, the overall postoperative complication rate significantly differed. Postoperative pain was more common after surgery alone vs after surgery plus EIPL. Improved safety and reduced postoperative short-term complications and wound pain could be seen in D2 gastrectomy by including EIPL. As a new, safe, and easy procedure, EIPL therapy could be readily conducted anywhere and does not need any special devices or techniques, and those with advanced gastric cancer seemed to be good candidates for it.

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