Boehle A, et al. - An unselected cohort of men with unfavorable (NCCN intermediate and high-risk) PCa getting combined-modality radiation treatment (CRT) was assessed for outcomes and complication rates. Researchers administered androgen deprivation therapy for 1 year and CRT consisting of external-beam radiotherapy (EBRT, 59.4 Gy, 33 fractions) and ¹²⁵J seed-brachytherapy (S-BT, 100 Gy) to patients. Outcomes revealed CRT was an outstanding treatment option for these men. In univariate and multivariate analysis, they identified a group of patients with unfavorable outcomes with initial PSA (iPSA) > 20 ng/ml, comprising 24% of all patients, in which 55% of recurrences, 54% of metastases and 71% of cancer-specific deaths occurred. Limited side-effects were evident; after 5 years, only < 5% of patients complained of genitourinary AEs and 0.5% complained of gastrointestinal AEs.