Awad MA, et al. - In this study that included 100 combined heart and kidney transplantation (HKTx) procedures that were performed from June 1992 to December 2016, researchers assessed the long-term survival post-HKTx, the influence of age and dialysis status, the rates of cardiac rejection, and the influence of sensitization. Comparisons involving older aged (≥ 60 years; n=53) vs younger aged (< 60 years; n=47) recipients, as well as recipients on preoperative dialysis (n=49) vs not on dialysis (n=51), were performed. The investigators analyzed actuarial freedom from any cardiac rejection, acute cellular rejection, and antibody-mediated rejection, and survival rates by sensitized status with panel-reactive antibody levels < 10%, 10% to 50%, and > 50%. Using the United Network for Organ Sharing database, they compared these survival rates. Findings revealed the safety of HKTx as a procedure in patients aged 60 years and older or younger than 60 years of age (with or without dialysis dependence). HKTx offered excellent outcomes. Survival after HKTx was not influenced by the degree of panel-reactive antibody sensitization.