Vaillant L, et al. - Researchers conducted this randomized, double-blind, 4-arm crossover, clinical pharmacology study to assess the impact of an emollient, V0034CR cream, and its active ingredients, to restore the cutaneous barrier, as well to evaluate the moisturizing activity of each product and tolerance. The research was not intended to assess the therapeutic benefit. For this investigation, the full emollient V0034CR, its vehicle formulation alone, or with glycerol, or petrolatum, was applied to the forearms of healthy volunteers (n = 51) with dry skin (Kligman score of 2 or 3). According to findings, the emollient V0034CR had combined effects, with the petrolatum component improving skin barrier function, reducing TEWL, and improving skin hydration by the glycerol component.