Buttle SG, et al. - Given that seizure monitoring through amplitude-integrated EEG is standard of care in many neonatal intensive care units, however, conventional EEG is the gold standard for seizure detection, researchers compared the diagnostic yield of amplitude-integrated EEG interpreted at the bedside, amplitude-integrated EEG interpreted by an expert, and conventional EEG. For an average duration of 33 hours, 13 neonates were monitored. According to findings, real-world bedside amplitude-integrated EEG monitoring failed to detect all seizures demonstrated through conventional EEG while misclassifying other events as seizures. Data reported that even post hoc expert amplitude-integrated EEG interpretation presented limited sensitivity and specificity. Taking into account the poor sensitivity and specificity of bedside amplitude-integrated EEG interpretation, combined monitoring can provide limited clinical benefit.