Shen J, et al. - Researchers compared combination treatment with cetuximab vs conventional treatment in nasopharyngeal carcinoma (NPC) patients, focusing on benefits and safety. They also assessed skin toxicity (ST) related to additional cetuximab. For this purpose, they performed a meta-analysis of 23 relevant studies identified from PubMed, Embase, Cochrane library, China National Knowledge Infrastructure, and WanFang Data via a systematic search. The studies opted for this analysis included those reporting the aforementioned comparison, with completely or partly reported clinical outcomes including survivals, complete and partial responses, and adverse reactions. Findings revealed that compared with conventional treatment, improved efficacy on increased objective response rate and prolonged survival were offered by combination treatment with cetuximab. Overall, these patients can derive more benefits from additional cetuximab treatment, while conventional treatment showed limited effectiveness. To guide treatment with cetuximab against NPC, a potential on-treatment marker could be ST associated with cetuximab.