Chen Y, et al. - In the present study, brain radiotherapy (RT) in combination with tyrosine kinase inhibitors (TKIs) was compared with TKIs alone regarding its efficacy for advanced lung adenocarcinoma (LAC) patients with epidermal growth factor receptor (EGFR) mutations and brain metastasis (BM). Among 78 patients diagnosed with EGFR-mutant LAC who developed BM, 49 patients received brain RT in combination with EGFR-TKIs (including 23 patients with asymptomatic BM before RT) and 29 patients received EGFR-TKI targeted therapy alone (including 22 patients with asymptomatic BM before TKI treatment). Compared with EGFR-TKIs alone, the synchronous combination of brain RT and TKIs was identified as superior for EGFR-mutant LAC patients with BM. They noted longer intracranial progression-free survival in correlation with the combination treatment group, while the two groups were not significantly different regarding the PFS and OS. In addition, those with asymptomatic BM could show better iPFS and OS on receiving the combination treatment. Therefore, the addition of brain RT was inferred as valuable for intracranial metastatic lesions.