Jan HC, et al. - Analyzing the clinical data of 424 patients who underwent radical nephroureterectomy from January 2007 to June 2017, researchers evaluated the clinical value of the preoperative systemic immune-inflammation index (SII) combined with the monocyte-lymphocyte ratio (MLR) for patients with upper-tract urothelial carcinoma (UTUC). Outcomes demonstrated the ability of combined SII and MLR to predict disease progression and survival. They observed a significantly higher likelihood of having a non-organ-confined disease and poor survival outcomes for patients with both high SII and high MLR.