Tan J, et al. - Researchers intended to analyze the correlation of SIRT1 and Src with human breast cancer (BC) prognosis. They also explored the roles of SIRT1 and Src in BC cell proliferation, tumor invasion, and metastasis; and assessed the correlation and interaction between SIRT1 and Src. SIRT1 and Src overexpression, both, showed a correlation with poor prognosis in human BC. For luminal-type BC, SIRT1 + Src (SIRT1 and/or Src positivity) was acknowledged as a fine prognosis model. In BC migration and invasion, but not in cell proliferation, SIRT1 was found to be a copromotor of Src. A potential interaction or a common regulation pathway was suggested between SIRT1 and Src expression and activity.