Kim SH, Kim ER, Kim K, et al. - In this single-center prospective randomized controlled study involving 168 patients, researchers compared the effectiveness of bowel cleansing between the 2L PEG-Asc (control) and 1L PEG-Asc with bisacodyl suppository (suppository) groups, as well as examined complications and tolerability between the two groups. Participants in the study were patients scheduled for colonoscopy between August 2017 and January 2018 and randomly assigned them to the control or the suppository groups. Findings revealed that there was no significant difference in baseline characteristics including insertion and withdrawal times, and detection rates of adenoma between the two groups. Data reported that the total BBPS score in the control and suppository groups was 7.93 ± 1.06 and 7.74 ± 1.02, respectively. The incidence of abdominal pain and nausea did not differ statistically, whereas in the control group the incidence of sleep disturbance and anal discomfort was higher. Compared with 2L PEG-Asc, 1L PEG-Asc with bisacodyl suppository led in an equivalent bowel cleansing outcome with decreased patient discomfort. PEG-Asc with bisacodyl suppository, therefore, represents a potential alternative and increases compliance with bowel preparation by the patient.