Gianakos AL, Romanelli F, Rao N, et al. - A systematic review of the literature was conducted to explore postoperative outcomes following a single site and combined peripheral nerve blocks (PNBs), including sciatic and femoral nerve, popliteal and saphenous nerve, and popliteal and ankle nerve, during the elective foot and ankle surgery. Researchers conducted a review of the literature according to the PRISMA guidelines. They carried out to search Medline, EMBASE, and the Cochrane Library from January 2009 to October 2019. They distinguished studies by applying synonyms for “foot”, “ankle” “pain management”, “opioid”, and “nerve block”. In comparison with patients who did not receive PNB, this research distinguished substantial improvement in postoperative pain levels, postoperative opioid consumption, and patient satisfaction in patients receiving PNB. For all data points, published data also indicated that combination PNB is more effective than single-site PNB. The results considered that the addition of a femoral nerve block to a popliteal nerve block during the use of a thigh tourniquet, as well as the addition of either saphenous or ankle blockade to popliteal nerve block during the use of calf tourniquet, may elevate overall block effectiveness.