Backes Y, et al. – This prospective study was performed to assess the feasibility and safety of a new, flat–based over–the–scope clip (Padlock Clip) for colorectal endoscopic full–thickness resection (eFTR). Feasibility was demonstrated in this first series of colorectal eFTR using the Padlock Clip. In view of surgery as the alternative treatment, it was relatively safe, but could still benefit from technical refinement. Future studies had to explore for which indication this technique was most suitable.