., et al. - The study attempted to illustrate the frequency and prognostic significance of molecular subgroups in colorectal diffuse large B-cell lymphoma (DLBCL). Researchers analyzed 25 cases of colorectal lymphoma with DLBCL-like morphology and divided them into germinal center B-cell like (GCB)/non-GCB subgroups by immunohistochemistry (IHC) for CD10, bcl-6 and MUM1, or into double-expressor (DE)/non-DE subgroups by IHC for bcl-2 and c-myc. They categorized 25 cases into two entities—DLBCL, not otherwise specified (NOS) (n = 23; 92%) and high-grade B-cell lymphoma, double hit (n = 2; 8%)—according to the recent WHO classification. It was noted that translocations including at least one of the IGs may be a favorable prognostic factor in colorectal DLBCL. Examining the translocation including the rearrangement of IGs as well as MYC and BCL2/BCL6 may, therefore, be beneficial for diagnosis and prognosis.