Jodal HC, et al. - In this systematic review and network meta-analysis of 12 randomized trails, researchers assessed the efficiency, harms, and burdens of fecal blood testing, sigmoidoscopy, and colonoscopy screening for colorectal cancer over 15 years. Compared with no-screening, sigmoidoscopy screening slightly decreased colorectal cancer incidence and mortality. On the other hand, guaiac fecal occult blood test (gFOBT) screening had little or no impact on colorectal cancer incidence, but slightly decreased colorectal cancer mortality. No screening test decreased mortality nor incidence by more than 6 per 1,000 screened over 15 years. For both colorectal cancer incidence and mortality, sigmoidoscopy had a higher impact in men. Hence, in a 15-year perspective, sigmoidoscopy was found to decrease colorectal cancer incidence, whereas sigmoidoscopy, annual and biennial gFOBT all decrease colorectal cancer mortality. Moreover, sigmoidoscopy could decrease colorectal cancer incidence and mortality more in men vs women.