Colorectal adenomas and cancers after childhood cancer treatment: A DCOG-LATER record linkage study
Journal of the National Cancer Institute Jul 16, 2018
Teepen JC, et al. - Researchers examined participants in the DCOG-LATER cohort study to assess the risk of histologically confirmed colorectal adenomas in childhood cancer survivors as well as colorectal cancer (CRC) risk. They found that childhood cancer survivors had excess risk of colorectal adenomas and CRCs. The identified factors conferring risk for adenoma included abdominopelvic radiotherapy, total body irradiation, cisplatin, and procarbazine. The factors that were confirmed to be conferring strong risk were hepatoblastoma (familial adenomatous polyposis-associated) and family history of early-onset CRC.
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