Moon HG, Kim SJ, Lee MK, et al. - Using a murine model of chronic asthma, researchers assessed the therapeutic efficacy of CSF1 and CSF1R inhibition for blocking the dendritic cell function of sensing aeroallerens. For inducing asthma, they used a panel of three naturally occurring allergens and new delivery system of CSF1R inhibitor encapsulated nanoprobe. Findings revealed effective suppression of sensitization to aeroallergens by inhibiting the CSF1-CSF1R signaling pathway in a murine model of chronic asthma, which ultimately caused suppression of allergic lung inflammation. Overall, CSF1R inhibition was identified as a promising novel target for the treatment of allergic asthma.