Guglielmi V, LeCouffe NE, Zinkstok SM, et al. - In a population of individuals who had endovascular treatment for large vessel occlusion, researchers investigated whether patients with ischemic stroke due to cervical carotid atherosclerosis have more extensive collateral circulation and better outcomes compared with patients with cardioembolism. The study population included consecutive adult endovascular treatment patients (March 2014 to June 2016) with acute ischemic stroke due to anterior circulation large vessel occlusion, and the investigators compared patients with cervical carotid artery stenosis > 50% to those with cardioembolic etiology from the MR-CLEAN Registry (Multicenter Randomized Controlled Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands). In all, 190 individuals with cervical carotid atherosclerosis and 476 patients with cardioembolism were included. Compared with individuals with cardioembolism, those with cervical carotid atherosclerosis were younger (median 69 vs 76 years), more often male (67% vs 47%, P<0.001), more often had an internal carotid artery terminus occlusion (33% vs 18%), and lower prestroke mRS (mRS score, 0–2; 96% vs 85%). Stroke due to cervical carotid atherosclerosis was linked to higher collateral score and lower median mRS at 90 days compared with cardioembolic stroke. No statistically significant difference was observed in the proportion of mRS 0–2 or mortality at 90 days.