Tan Q, Jacobsen R, Nygaard M, et al. - Survival analysis was carried out using two cohorts of long-lived people born in 1905 and 1915 in Denmark in order to estimate the risk on mortality of major candidate genes of aging and longevity as well as their cohort effects. Researchers estimated the comparative risks of genetic variants in APOE, FOXO3A, CLU, and PICALM on death from age 95 to 103, via statistical modeling that merges individual genetic and survival data with cohort-specific survival data. Among men in the later cohort, reduced risk of carrying the APOE ε4 allele was noted although the allele itself was found to be harmful to survival across genders. Experts also estimated a cohort impact of a heightened risk of the minor allele of rs3851179 in PICALM with borderline significance in women. The significant cohort effect on APOE ε4 estimated in this study was suggestive of the interplay between gene and the changing environment that modulates survival at extreme ages.