Coffee and pancreatic cancer risk among never-smokers in the UK prospective Million Women Study
International Journal of Cancer Jan 04, 2019
Zhou CD, et al. - Researchers assessed the link between coffee consumption and pancreatic cancer risk among never-smokers in the UK prospective Million Women Study, using Cox regression. Participants were 309,797 never-smoking women who were inquired to self-report typical daily coffee consumption at a mean age of 59.5 years (standard deviation 5.0 years). Through record linkage to national health cancer and death registries, the participants were followed up for a median of 13.7 years (IQR: 12.2–14.9), during which 962 incident cases of pancreatic cancers were registered. In never smokers, little or no statistically significant link was found between coffee consumption and pancreatic cancer risk, as revealed in the meta-analysis of results from this cohort and 3 smaller prospective studies. Among never-smokers who reported usually consuming 1–2, 3–4, and ≥ 5 cups of coffee daily, vs nondrinkers of coffee, relative risks (RRs) of pancreatic cancer were 1.02 (CI 0.83–1.26), 0.96 (0.76–1.22), and 0.87 (0.64–1.18), respectively (trend p = 0.2), after adjustment for potential confounding factors, including body mass index and alcohol consumption.
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