Yuan S, Larsson SC, et al. - A reduction in kidney stones may be conferred by higher coffee and caffeine intake.

• Observational studies have shown a lower risk of kidney stones in relation to coffee and caffeine intake.

• The causal nature of these associations was tested via this Mendelian randomization study utilizing genetic data.

• In the UK Biobank study, a lower risk of kidney stones was evident in relation to genetically predicted coffee and caffeine consumption, and the links were directionally similar in the FinnGen consortium.

• Per a genetically predicted 50% increase and 80-mg increase in caffeine intake, combined odds ratio of kidney stones was 0.60 and 0.81, respectively.