Crabb SJ, et al. - In view of the efficacy of aspirin in minimising gentamicin-induced ototoxicity, researchers here tested the hypothesis that aspirin could also reduce ototoxicity from cisplatin-based chemotherapy. They observed no protective effect of aspirin against cisplatin-related ototoxicity. Thereby suggesting distinct ototoxic mechanisms of cisplatin and gentamicin, or cisplatin-induced ototoxicity may be refractory to the aspirin regimen used here.