Benediktsson S, et al. - Utilizing retrospectively gathered data, researchers determined if prothrombin time (PT-INR) and activated partial thromboplastin time (APTT) at admission can serve as predictors of outcome in the critically ill patient following adjustment for severity of illness measured with Simplified Acute Physiology Score 3 (SAPS 3). This analysis involved 3,585 ICU patients. They reported organ failure as days alive and free (DAF) of vasopressors and invasive ventilation, the requirement of continuous renal replacement therapy and Acute Kidney Injury Network creatinine score. Findings revealed a link of APTT prolongation with mortality and all morbidity outcomes except the DAF ventilator. PT-INR rise at admission was found to be related to DAF vasopressor and DAF ventilator. Findings revealed that APTT and PT-INR at admission correlated with morbidity, which is not accounted for in the SAPS 3 model.