Benediktsson S, et al. - Whether the outcome in the critically ill patient can be predicted by prothrombin time (PT-INR) and activated partial thromboplastin time (APTT) at admission, following adjustment for severity of illness measured with Simplified Acute Physiology Score 3 (SAPS 3), was investigated in this study. Researchers analyzed retrospectively obtained data for 3,585 ICU patients. Regression analyses, including independent variables such as APTT and PT-INR recorded on admission and SAPS 3 score, were performed. Organ failure was described as days alive and free (DAF) of vasopressors and invasive ventilation, a requirement for continuous renal replacement therapy and Acute Kidney Injury Network creatinine score. Findings revealed the link of APTT prolongation with mortality and all morbidity results except the DAF ventilator. The link of PT-INR rise at admission with DAF vasopressor and DAF ventilator was also identified. Experts found a correlation of APTT and PT-INR at admission with morbidity, which was not accounted for in the SAPS 3 model.