Shayo FK - Among 3,793 in-school adolescents in Tanzania, the researcher sought to determine the prevalence, sociodemographic distribution, as well as the co-occurrence of risk factors for non-communicable diseases (NCDs). Among participants, the prevalence of co-occurrence of lifestyle health-risk factors for NCDs was found, which was significantly higher among younger adolescents. The combination of risk factors which prevailed the most among the participants was: unhealthy diet and physical inactivity 666 (17.6%); unhealthy diet and suicide attempt 151 (4.0); unhealthy diet and tobacco use 98 (2.8); and unhealthy diet, physical inactivity, and suicide attempt 81 (2.1). Compared to a single risk factor approach, the efficacy of a multi-strategy public health intervention program may be greater and, thus, is suitable for resource-limited settings, such as Tanzania.