Wu P, Xiong H, Yang M, et al. - A total of 313,704 women (4,933 HPV16/18-positive women) aged ≥ 30 years were screened in China in order to assess whether co-infected with other high-risk (hr) Human papillomavirus (HPV) types would influence the risk of cervical carcinogenesis in HPV16/18 positive women. The risk of acquiring cervical intraepithelial neoplasia (CIN) grade 3 or greater (CIN3+) was significantly lower in HPV16 + other hrHPVs group, in comparison with single HPV16 infection, following adjusting for cofactors. Thus, HPV16/18 co-infection with other hrHPVs is a prevalent phenomenon. The risk of cervical carcinogenesis may be affected by distinct HPV16/18 infection patterns. Moreover, in ≥ 30 years old women, HPV16 co-infected with other hrHPVs seems to have a lower correlated risk of CIN3+.