Li H, Liu YT, Chen L, et al. - Researchers conducted the study for analyzing the role of CMTM4 in head and neck squamous cell carcinoma (HNSCC). Immunohistochemistry and Western blot analysis revealed that CMTM4 was overexpressed in human and mouse HNSCC samples as well as HNSCC cell lines. A high level of CMTM4 expression was associated with advanced lymph node metastasis and a poor prognosis. The findings suggested that CMTM4 may be involved in the regulation of epithelial-mesenchymal transition/cancer stem cell phenotypes and PD-L1 expression. This study could increase interest in CMTM4 as a potential target for HNSCC prognosis and treatment.