Prior TS, Hoyer N, Hilberg O, et al. - This research sought to comprehensively and prospectively evaluate comorbidities in a multicentre, real-world cohort of patients with idiopathic pulmonary fibrosis (IPF), including prespecified conditions of special interest and to examine clusters of comorbidities and analyze characteristics, disease course and mortality of the clusters. Researchers used several measurements, questionnaires, medications and medical history to evaluate comorbidities. Self-organizing maps were used to distinguish clusters of comorbidities and phenotypes characterized. Using mixed effects models, disease course was evaluated and mortality was assessed by using Cox regression. The study enrolled 155 IPF patients prospectively. In patients with IPF, multimorbidity is prevalent. The data demonstrate that four specific clusters of comorbidities may represent phenotypes in IPF. According to the findings, a trend towards faster decline in exercise capacity and dyspnea was found in patients with fewer comorbidities. In patients with IPF, increased knowledge of comorbidities facilitates prevention and treatment of comorbidities.