Aslıer M, Aslıer NGY, Ercan I, et al. - The causatives of otitis media with effusion (OME) include adenoid hypertrophy (AH) and OME is identified to be the most common causative of childhood hearing loss. Although, there may be involvement of other upper airway-related predisposing factors such as, location of the adenoid, accompanying tonsillar hypertrophy (TH) and nasal septal deviation (NSD) for the development of OME. Researchers herein investigated the correlations between the upper airway physicals and OME with auditory functions. This prospective clinical study was performed including 86 ears of 43 children, aged 3–11 years. Clustering led to the unveiling of two groups of ears; cluster-1 (n = 46) and cluster-2 (n = 40), at the similarity level of 0.662. The two clusters significantly differed in the presences of AH, adenoid around torus tubarius, OME and the medians of adenoid choana percentage (ACP), peak pressure, resonance frequencies, wideband tympanometry ambient pressure absorbance ratios at all frequencies except 5,656 Hz and 8,000 Hz, all PTA thresholds were significantly different between two clusters. Observations revealed correlations between AH, AATT and OME together with reduction in hearing and SEA. Whereas, there was no correlation of TH and NSD with the formation of clusters and they are insignificant factors.