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Clustering of cutaneous T-cell lymphoma is associated with increased levels of the environmental toxins benzene and trichloroethylene in the state of Georgia

Cancer Jan 29, 2020

Clough L, Bayakly AR, Ward KC, et al. - Using the Georgia Cancer Registry, researchers examined the links between geographic clustering of cutaneous T-cell lymphoma (CTCL) incidence in the state of Georgia with benzene and trichloroethylene (TCE) exposure. They collected statewide county-level incidence of CTCL within Georgia for the years 1999 to 2015. They used spatial analyses to analyze the clustering of CTCL. As per the findings, the geographic clustering of CTCL was significant in Georgia, especially around Atlanta, and there was a correlation of geographic clustering of CTCL with an increased level of benzene and TCE exposure. CTCL incidence was found to be between 1.2 and 1.9 times higher, compared with the state average, and the reported levels of benzene and TCE were between 2.9 and 8.8 times higher, among the 4 most populous counties in Georgia. Nonrandom geographic clustering of CTCL incidence in Georgia was shown. An association between geographic clustering of CTCL and environmental toxic exposures was identified for the first time ever in this study.
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