Niu X, et al. - The efficacy and safety of transcatheter device closure (TDC) plus anti-thrombotic drugs were examined over medical management alone for patients with cryptogenic stroke and patent foramen oval. Compared to medical therapy alone, TDC plus anti-thrombotic drugs was superior for secondary prevention of stroke, particularly for those with male gender and with substantial shunt size of foramen ovale. It would not bring a higher risk of all-cause mortality, total adverse events and bleeding, though it could increase the risk of postoperative atrial fibrillation.