Yuan L, et al. - This study intended to present the clinicopathological significance of lymphocytic colitis/collagenous colitis in inflammatory bowel disease. Researchers examined a sum of 27 individuals with the diagnosis of either ulcerative colitis (UC) or Crohn disease (CD) and LC/CC. Clinical, endoscopic, and pathological features were analyzed. After a median interval of 14 months, ten individuals with initial diagnoses of LC (n = 2)/CC (n = 8) evolved into UC (n = 7) or CD (n = 3) (range, 2-44 months). The data indicated that LC/CC may be a spectrum of IBD as the initial presentation in a subset of older IBD individuals. IBD individuals can develop LC/CC correlated with chronic mucosal injury many years after the onset of IBD (typically with >10 years interval time while patients are in remission phase), for which these 2 processes appear unrelated to each other.