Yamanouchi M, et al. - In this retrospective analysis of patients with biopsy-proven nephrosclerosis in Japan, researchers intended to determine the clinicopathological predictors for progression of chronic kidney disease (CKD). For various clinical and histological characteristics in competing risks analysis, the sub-distribution hazard ratio (SHR) with 95% confidence interval (CI) for CKD progression was determined. The risk factors for CKD progression, as identified in multivariable sub-distribution hazards model, included serum albumin, hemoglobin A1c, estimated glomerular filtration rate (eGFR), urinary albumin/creatinine ratio (UACR), percentage of segmental/global glomerulosclerosis (%GS) and interstitial fibrosis and tubular atrophy (IFTA). Overall, for better prediction of CKD progression in patients with nephrosclerosis, the markers of serum albumin and hemoglobin A1c as well as the biopsy data, especially the data on the severity of interstitial damage, may be explored in addition to the traditional markers of eGFR and UACR.