Zhu L, et al. - Researchers studied clinicopathological features, treatment patterns and prognosis of squamous cell carcinoma (SCC) of the breast, using data from the national cancer database. A 1:4 SCC-IDC (infiltrating ductal carcinoma) matching analysis was done with patients diagnosed between 2004 and 2014. The clinicopathological features and treatment patterns between SCC (n = 686) and IDC (n = 2744) patients were compared using Chi-square test. Findings revealed the association of SCC with poorer clinicopathological features, no responses to neoadjuvant chemotherapy and worse clinical outcomes, compared to IDC. Also, there was a difference in treatment patterns between SCC and IDC. For SCC patients, breast conserving surgery (BCS), as well as radiotherapy after BCS, was reported less often. Among those having a low-risk, SCC patients vs IDC patients were more often treated with chemotherapy, 42.9% vs 18.7%, respectively. Among those who were hormone receptor (HR)-positive, a less often use of endocrine therapy was reported in SCC patients (51.6%) than for IDC patients (70.5%) (p < 0.001). Endocrine therapy was considered necessary for HR-positive SCC patients.