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Clinicopathological features and risk factors for developing colorectal neoplasia in Hodgkin lymphoma survivors

Digestive Endoscopy Jun 12, 2021

Ykema BLM, Rigter LS, Spaander MCW, et al. - Among Hodgkin lymphoma (HL) survivors, clinicopathological features as well as risk factors for developing (advanced) neoplasia (AN) were investigated in this study. Overall, 101 HL survivors (median age 51 years, median age of HL diagnosis 25 years) had colonoscopy and 350 neoplasia and 44 AN (classified as advanced adenomas/serrated lesions or colorectal cancer), mostly right-sided, were identified, as published earlier. Controls (median age 60 years) included an average-risk asymptomatic cohort who had screening colonoscopy. Findings indicate difference in colorectal neoplasia between HL survivors and average-risk controls; classification AN mainly based on polyp size (≥10 mm) in HL survivors. Among HL survivors, a higher prevalence of AN was observed in relation to longer follow-up between HL diagnosis and colonoscopy.

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